Parkinsons term paper Essay Example for Free

Parkinsons term paper Essay Parkinsons disease is characterized as a degenerative disorder of the central nervous system which is understood to persist and continually worsen over time. It is the second most common neurological disorder. Parkinson’s disease affects approximately one million people within the United States. This disorder progresses slowly and is unique in the sense that Parkinson’s disease can be caused by genetics among other things. Parkinson’s disease is well known for its characteristic tremors, stiffness, and difficulty with speech in the patients it affects. Parkinson’s disease is caused by diminishment of the substantia nigra in the tegmentum which controls motor functions within the body. This disease is classified as a basil ganglionic disorder which causes a breakdown of dopamineric neurons in the substancia nigra, located in the midbrain. The substancia nigra is composed of neuromelanin which pigments the substancia nigra and gives it its darker characteristic. The neuromelanin also connects to the motor cortex which is responsible for one’s motor control and balance. The chemical dopamine is created in the substantia nigra. The basil ganglia receives inputs from the motor cortex, the association cortex, and the substancia nigra. The basil ganglia then sends messages to the motor cortex by way of the thalamus. With Parkinson’s disease, the nigral neurons are damaged, which causes the neuromelanin to be free to move into the adjacent tissue where it is phagocytosed and moved away by macrophages. This degenerative process not only destroys the process of creating dopamine, but it also causes the pigmentation of the substancia nigra to change and become lighter in appearance. The lack of dopamine-related input from the substantia nigra negatively changes the equilibrium of the output from the basil ganglia to the motor cortex. This alteration in the equilibrium then causes the symptoms related to Parkinson’s disease. The d irect cause of Parkinson’s disease remains a medical mystery, but many factors can participate in determining whether one is susceptible to developing Parkinson’s disease in  the future. The exposure to specific toxins in the environment and various environmental factors has the possibility of playing a role in those who were diagnosed with Parkinson’s disease. Another possible cause of Parkinson’s disease is the role of one’s genetics. It is found that certain mutations can give rise to Parkinson’s disease, although this is uncommon. The brains of patients with Parkinson’s disease change as the disease progresses. Lewy bodies are microscopic markers that characterize the presence of Parkinson’s disease within a patient. They are abnormal microscopic protein deposits that form in the brain and play a role in disrupting the brain’s normal functions. This disruption causes deterioration. Lewy bodies contain A-synuclein which is a protein that cells cannot break down. Early indicators of Parkinson’s disease include tremors or shaking which can reside in one’s finger, thumb, hand, lip, or chin, though shaking is normal after extensive physical activity, injury, or may be due to medications. If one’s handwriting begins to appear smaller over a short period of time, it could be a warning sign of Parkinson’s although one should not base their self-diagnosis upon handwriting, for handwriting can change as one advances in age, but this happens over time and not suddenly. A loss of smell in specific foods can be an indicator, but a loss of smell can also be related to the possession of the common cold or the flu. Another early sign may be sudden movements while sleeping such as falling out of the bed or kicking and punching. It is important to understand that people on occasion may experience difficulty sleeping. Chronic stiffness can be a sign, but this symptom can also be caused by an injury or arthritis. If one is experiencing constipation on a daily basis, this can be considered a sign of Parkinson’s disease, although a lack of fiber in one’s diet or medications can determine the moving of one’s bowels. Having recently possessed a soft o r low voice is an indicator unless one has a chest cold or other virus. If one has the appearance of a masked face, a blank stare that persists, or undergoes a long duration of time without the action of blinking, these may be precursors to having Parkinson’s disease. Feeling dizzy or fainting can be signs of low blood pressure and may be connected to Parkinson’s disease along with the inability to stand up straight. There are many Parkinson’s-related symptoms that are known today. The most obvious of symptoms is a resting tremor. A shaking, or tremor, normally starts in one’s  limb, and it is often located on a hand or fingers. This resting tremor usually stops when the patient is voluntarily moving the limb affected by the tremor. A â€Å"pill-rolling† tremor is common and is characterized by one rolling one’s thumb and forefinger. These tremors can be noticed when the limb is even at a relaxed state. Due to the tremors and inability to control certain motor functions, writing can become difficult for patient s with Parkinson’s disease. It is noted that when writing, those effected with Parkinson’s disease posses handwriting that is characteristically small. Bradykinesia, or a slowing of movement, can be present. Parkinson’s disease has the ability to cause one to move slower which can make simple every-day tasks a challenge. With bradykinesia, one’s steps may become smaller in distance when being mobile, and one’s feet may begin to drag when walking. Excessive muscle tone or hypertonia may be prevalent in patients with Parkinson’s disease and will manifest itself as stiffness or rigidness which causes pain and a loss in one’s range of motion. Parkinson’s disease patients may experience posture impairment and balance, for a patient’s posture can become stooped, and balance can be lost. Patients diagnosed with Parkinson’s disease may experience a loss in their autonomic functions which include and are not limited to smiling, swinging one’s arms while walking, and blinking. This loss in autonomic function caused a select number of patients to stop using their hands while speaki ng in normal conversations. Speech changes can affect those living with Parkinson’s disease. One may speak out of rhythm in such a way that it may sound soft, quick, hesitant, monotone or slurred. Diagnosing Parkinson’s disease is not a simple process, for a test for Parkinson’s disease does not yet exist. In order to be diagnosed with Parkinson’s disease, a neurologist must first obtain a detailed medical history of the patient being diagnosed, a review of the patient’s signs and symptoms, a physical examination, and a neurological examination. Tests to exclude other conditions may be ordered to ensure proper diagnosis of the disorder. Once a patient has undergone sufficient testing and examining, the doctor may prescribe the patient the medication carbidopa-levodopa, which is a Parkinson’s disease medicine. If the patient improves considerably while on the medication, this often confirms a Parkinson’s disease diagnosis.  There exists a wide-range of treatments for patients that suffer from Parkinson’s disease from drug treatments to surgical treatments. The pharmacologic approach for those with Parkinson’s disease aims to increase the lack of dopamine in the patient’s basil ganglia. L-dopa or Levodopa is a drug that can cross the blood-brain barrier. The brain can convert this drug to dopamine. Carbidopa can also be prescribed to patients afflicted with Parkinson’s disease. Carbidopa is a decarboxylase inhibitor and, when taken with levodopa, can aid levodopa from converting to dopamine outside of the brain. The combination of medications allows for more levodopa to reach the brain which ultimately increases the brain’s supply of dopamine. These two medications decrease the side effects which are caused by an increased amount of dopamine outside of the brain. They reduce the supply of â€Å"free† dopamine from residing outside of the brain. An excess of dopamine outside of the brain could result in low blood pressure, vomiting, and nausea. Other medications include dopamine agonists which directly stimulate nerve receptors inside of the brain which are usually stimulated by dopamine. In contrast to the medication levodopa, dopamine agonists do not convert into dopamine but rather behave like dopamine. Dopamine agonists are utilized in patients that are in the early stages of Parkinson’s disease and may be added to a treatment plan along with levodopa in the later stages of Parkinson’s disease. It may also be added when levodopa alone cannot sufficiently manage the patient’s symptoms or when the patient has severe motor fluctuations. Side effects associated with levodopa-carbidopa include dizziness upon rising, confusion, nausea, movement disorders, and hallucinations. Side effects commonly associated with dopamine agonists are vomiting, nausea, and orthostatic hypotension. Surgical treatment options are available for those who suffer from Parkinson’s. These surgical treatments are intended to control symptoms related to Parkinson’s disease patients who do not positively respond to medications. One of the surgical treatments crea tes a lesion in specific portions of the thalamus within the midbrain which become overactive in Parkinson’s disease. A reversible procedure that can be used on patients diagnosed with Parkinson’s disease is deep brain stimulation, or DBS. With this procedure, electrodes are implanted into exact locations. These locations are treated then with pulses of electrical currents. Why deep brain stimulation works is unknown. Medical  experts believe that the current could be activating, affecting, or inhibiting synaptic transmission onto neurons in the vicinity of the electrodes. The future prospects for a cure for Parkinson’s disease are promising, for the medical community has begun to identify the genetic causes linked to Parkinson’s disease. This allows the medical community to expand animal models of Parkinson’s disease. These will be highly useful in the process of understanding the pathogenesis of the disease and will be useful in further testing the neuroprotective therapies which can potentially aid in the fight against the progression of Parkinson’s disease. A different potential approach in the future would be to engage in the replacement of lost neurons via transplantation, which would be highly difficult and tedious. Overall, Parkinson’s disease is well on the way to being better understood and through this und erstanding scientists will be able to directly identify the source of this disease and eventually find a method that directly cures this disease. References Etiology. (n.d.). Merriam-Webster. Retrieved March 13,2014, from http://www.merriam-webster.com/dictionary/etiology Welcome to the Purdue OWL. (n.d.). Purdue OWL: APA Formatting and Style Guide. Retrieved March 13, 2014, from https://owl.english.purdue.edu/owl/resource/560/01 Parkinson’s: Symptoms Types. (n.d.). WebMD. Retrieved March 13, 2014, from http://www.webmd.com/parkinsons-disease/guide/parkinsons-symptons-types Parkinson’s disease. (n.d.). Complications. Retrieved March 13, 2014, from http://www.mayoclinic.org/diseases-conditions/parkinsons-disease/basics/complications/con-20028488 Parkinson’s Disease. (n.d.). Parkinson’s Disease. Retrieved March 13, 2014, from http:// courses.washington.edu/conj/bess/parkinsons.html Nisipeanu, P. (n.d.). Parkinson’s Disease: Diagnosis and Clinical Management. Adverse Effects of Dopamine Agonists. Retrieved March 13, 2014, from http://www.ncbi.nih.gov/books/NBK27800/ Levodopa Medicines for Parkinsonâ€℠¢s Disease. (n.d.). WebMD. Retrieved March 13, 2014, from http:// www.wbmd.com/parkinsons-disease/levodopa-medications-for-parkinsons-disease Dopamine Agonists for Parkinson’s Disease. (n.d.). WebMD. Retrieved March 13, 2014, from

Terrorism and Airport Security Essay -- Exploratory Essays Research Pa

Terrorism and Airport Security The morning of September 11 was like any other. The sun rose from the east, and the day was full of life. People went to work as they were accustomed to, and everybody seemed safe from harms way. In airports across America: planes were taking their passengers to their destinations in record times. People went through airport security as usual, walking through the metal detector and sending their bags through the x-ray machines. Security at the airport was normal. Bags were checked for guns and explosives as they had been doing for many years. This seemingly routine day turned out to be far from normal. A group of people that belonged to Al-Qaeda had different plans for the people of the United States. On September 11th the men of Al Qaeda, a terrorist group that has been the center of attention for some time now, hijacked 4 planes and used them as guided missiles to attack the people and government of America. These attacks were not against military targets or troops, they were aimed at the innocent civilians of everyday life. These cowardly attacks are the reason that the U.S. has devoted more time to national security, specifically airport security (September, 2004). Paul Thompson has compiled a complete timeline of the events that took place, before and after 9/11. Thompson continued, " The scrambling of fighter aircraft at the first sign of trouble is a routine phenomenon. During the year 2000, there where 425 'unknowns' pilots who didn't file or diverted [sic] from flight plans or used the wrong frequency." He went on to say that " such scrambles before 9/11 were about two or three times a week. After 9/11 they went up to three or four times a day" (Thompson, 2002). Paul Bracken,... ...hannel_hsd_story.jsp?id=news/com03244.xml Terrorism. (2004, March 16) Wikipedia. Retrieved March 17, 2004 from the World Wide Web: http://en.wikipedia.org/wiki/Terrorism Tyson, J. (2004, February 2). How Airport Security Works. How stuff works. Retrieved March 20, 2004 from the World Wide Web: http://travel.howstuffworks.com/airport-security1.htm style='font-family:Geneva'>Thompson, P. (2002 October 29). Complete 911 Timeline. Center For Corporative Research. Retrieved March 21, 2004 from the World Wide Web: http://www.cooperativeresearch.org/timeline.jsp?timeline=complete_911_timeline&timeperiod=0:10am-11:50pm%2011%20Sept%202001 < style='font-family:Geneva'>United States Department of Homeland Security. (2004, March 16) Wikipedia. Retrieved March 17, 2004 from the World Wide Web: http://en.wikipedia.org/wiki/Department_of_Homeland_Securitypan>

In the name of the father Essay

Often a film conveys a message about a character through various film techniques. This is true in the film â€Å"In The Name of the Father†. This story is mainly about a young man who is arrested for a crime he did not commit and how a relationship between father and son deepens throughout the tragedy. The main character, Gerry Conlon, is first portrayed to the viewer as an unruly rebel but is later developed into a more docile and compliant character. The director, Jim Sheridon, uses film techniques such as costume design, dialogue and extended metaphors to convey the development of Gerry as a character. 1st paragraph: -1st time we see gerry, scruffy, uncut -costume design – baggy jeans, long hair, dirty appearance -gives idea that gerry doesn’t care about his appearance or what people think of him -as film progresses he sharpens up appearance -combed pulled back hair 2nd: -change also shown through dialogue -lawyer asks him if he is scared of the court: -he replies â€Å"i just don’t want to be humiliated again† -this brief piece of dialogue shows that he has now changed and does care what others think of him -helps viewer understand how desperate an innocent man can be in the fight for justice 3rd: -use of extended metaphor -viewer sees lawyer gareth pierce driving through a long tunnel while listening to gerrys story -this could be viewed as an extended metaphor for the long dark road gerry has gone down while fighting the legal system -as the story draws to a conclusion she reaches the end of the tunnel, or the ‘light at the end of the tunnel’ -could refer to the point in the story where gerry and the others are finally set free. Read more:  My Father Goes to Court by Carlos Bulosan

ACOSTA Surname Meaning and Origin

The Spanish and Portuguese surname Acosta originated as a name used to  refer to a person who lived on a riverbank or by the coast, or from the mountains (encostas). The name derives from the Portuguese da Costa, a cognate of English coast. Acosta is the 60th most common Spanish surname. Alternate Surname Spellings: COSTA, COSTAS, COSTES, DA COSTA, COSTE, COTE, LACOSTE, DELACOSTE, DELCOTE, CUESTA, COSTI Surname Origin: Spanish, Portuguese Where Do People With the ACOSTA Surname Live? According to  Forebears, Acosta is the 518th most common surname in the world. It is found most prevalently in Paraguay, where it ranks 14th in the nation, followed by Uruguay (16th), Argentina (20th), Cuba (27th), Dominican Republic (42nd), Venezuela (45th), Colombia (51st), Panama (73rd) and Mexico (78th).  Within Spain, Acosta is found most frequently in the Canary Islands, according to WorldNames PublicProfiler.  In the United States, the Acosta surname follows the patterns of most Hispanic surnames, being found most often in the states of Florida, Texas, California, Arizona, New Mexico, Nevada, Colorado, Illinois, New York, New Jersey, Vermont, and Connecticut. Acosta is also fairly common in eastern Canada, especially in Toronto and Quebec. Famous People With the ACOSTA Surname Joaquin Acosta -  19th-century Colombian explorer and writerMercedes de Acosta - American poet, playwright, and novelistCarlos Acosta - Cuban ballet dancerManny Acosta - Panamanian professional baseball playerHector Acosta - Dominican musician Genealogy Resources for the Surname ACOSTA 100 Most Common Spanish SurnamesHave you ever wondered about your Spanish last name and how it came to be? This article describes common Spanish naming patterns and explores the meaning and origins of 100 common Spanish surnames. How to Research Hispanic HeritageLearn how to get started researching  your Hispanic ancestors, including the basics of family tree research and country-specific organizations, genealogical records, and resources for Spain, Latin America, Mexico, Brazil, the Caribbean, and other Spanish speaking countries. Acosta Family Crest - Its Not What You ThinkContrary to what you may hear, there is no such thing as an Acosta family crest or coat of arms for the Acosta surname.  Coats of arms are granted to individuals, not families, and may rightfully be used only by the uninterrupted male-line descendants of the person to whom the coat of arms was originally granted.   The Acosta DNA Surname ProjectThe Acosta Family Project seeks to find common heritage through sharing of information and DNA testing. Any variant spellings of the Acosta surname are welcome to participate. ACOSTA Family Genealogy ForumThis free message board is focused on the descendants of Acosta ancestors around the world. Search past queries, or post a question of your own. FamilySearch - ACOSTA GenealogyAccess over 1.1 million free historical records and lineage-linked family trees posted for the Acosta surname and its variations on this free genealogy website hosted by the Church of Jesus Christ of Latter-day Saints. ACOSTA Surname Mailing ListThis free mailing list for researchers of the Acosta surname and its variations includes subscription details and searchable archives of past messages. Hosted by RootsWeb. DistantCousin.com - ACOSTA Genealogy Family HistoryExplore free databases and genealogy links for the last name Acosta. The Acosta Genealogy and Family Tree PageBrowse family trees and links to genealogical and historical records for individuals with the last name Acosta from the website of Genealogy Today. -----------------------References: Surname Meanings Origins Cottle, Basil. Penguin Dictionary of Surnames. Baltimore, MD: Penguin Books, 1967. Dorward, David. Scottish Surnames. Collins Celtic (Pocket edition), 1998. Fucilla, Joseph. Our Italian Surnames. Genealogical Publishing Company, 2003. Hanks, Patrick, and Flavia Hodges. A Dictionary of Surnames. Oxford University Press, 1989. Hanks, Patrick. Dictionary of American Family Names. Oxford University Press, 2003. Reaney, P.H. A Dictionary of English Surnames. Oxford University Press, 1997. Smith, Elsdon C. American Surnames. Genealogical Publishing Company, 1997. Back to Glossary of Surname Meanings Origins